Freeline Therapeutics Holdings Plc Depreciation and Amortization 5 year CAGR is 23.45% for the year ending December 31, 2022. Depreciation and Amortization involve the systematic allocation of the cost of tangible and intangible assets over their useful lives. CAGR, or the Compound Annual Growth Rate, quantifies the mean annual growth rate of an investment or financial metric over a specified time span, considering the influence of compounding. It is instrumental in determining the true annualized return on an investment.